Antimicrobial feed additives - del 3

Statens offentliga utredningar 1997:132

SOU 1997:132
225
Annex A: Avilamycin
A.1 Introduction
Avilamycin is a mixture of oligosaccharides of the orthosomycin group, that are produced by
3TREPTOMYCES VIRIDOCHROMOGENES
. Other members of this
group include curamycin and everninomycins (Wolf, 1973). Avilamycin is mainly active against
gram-positive
bacteria. The compound is used for growth promotion in swine and poultry, at dosages ranging from 5 to 40 ppm for swine and from 2.5 to 10 ppm for poultry. It has never been used for therapeutic purposes in either human or veterinary medicine but a related compund, everninomycins, has been suggested for evaluation in human therapy (Chopra
ET AL
, 1997; Nicas
ET AL
, 1997). In rats and swine, oral avilamycin is primarily excreted in faeces (Magnussen
ET AL